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Related Experiment Video

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Resting-State Functional Connectivity in Relapsing-Remitting Multiple Sclerosis with Mild Disability: A Data-Driven,

Gowthami Nair1, Sruthi S Nair1, Karumattu Manattu Arun2

  • 1Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India.

Brain Connectivity
|August 25, 2022
PubMed
Summary

Resting-state functional connectivity (RSFC) analysis revealed significant differences in brain networks between people with relapsing-remitting multiple sclerosis (RRMS) and healthy controls. Reduced connectivity was observed in RRMS, particularly in the anterior cingulate cortex and default mode network.

Keywords:
MVPAfunctional connectivitymultiple sclerosisresting state networks

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Area of Science:

  • Neuroimaging
  • Systems Neuroscience
  • Clinical Neurology

Background:

  • Resting-state functional connectivity (RSFC) studies in multiple sclerosis (MS) yield inconsistent findings.
  • Multivoxel pattern analysis (MVPA) offers an unbiased, data-driven method for identifying seed regions of interest (ROIs) in RSFC analysis.

Purpose of the Study:

  • To investigate RSFC differences between individuals with relapsing-remitting multiple sclerosis (RRMS) and healthy controls (HC).
  • To identify specific brain regions and networks affected by RSFC alterations in RRMS.

Main Methods:

  • Whole-brain connectome-wide MVPA was conducted on 50 RRMS patients (Expanded Disability Status Scale ≤4) and 50 age/gender-matched HCs.
  • Identified clusters with significant group differences in RSFC were used as seed ROIs for whole-brain seed-to-voxel analysis.

Main Results:

  • Significant RSFC differences were found in three clusters: anterior cingulate gyrus, right middle frontal gyrus, and medial frontal cortex.
  • Seed-to-voxel analysis revealed network-specific abnormalities, notably reduced connectivity in the anterior cingulate cortex and default mode network in the RRMS group.

Conclusions:

  • The study identified specific RSFC abnormalities in RRMS, particularly within the anterior cingulate cortex and default mode network.
  • These findings align with previous research and offer insights into the cognitive and clinical implications of RSFC alterations in RRMS.