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Updated: Aug 31, 2025

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
Published on: June 14, 2021
ACUTE EXACERBATION OF CHRONIC CENTRAL SEROUS CHORIORETINOPATHY AT THE SITE OF A RETINAL PIGMENT EPITHELIUM APERTURE
Stéphane Abramowicz1, Brigitte Pasteels, Laurence Postelmans
1Department of Ophthalmology, Brugmann University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Purpose:
To describe an atypical case of chronic central serous chorioretinopathy with acute exacerbation consisting of severe exudation at the site of a retinal pigment epithelium aperture.
Methods:
Case report.
Results:
A 39-year-old man presented with a recurrence of central serous chorioretinopathy in the right eye. Initial evaluation was notable for a retinal pigment epithelium aperture overlying a chronic avascular pigment epithelial detachment. He was initially treated with topical dorzolamide and indomethacin. During the follow-up, application of topical dermal steroid for a case of athlete's foot led to severe fibrinous exudation originating from the site of the retinal pigment epithelium aperture. Half-fluence verteporfin photodynamic therapy induced rapid and complete resolution of the retinal findings.
Conclusion:
Photodynamic therapy allowed for excellent resolution of an atypical exudative and fibrinous form of central serous chorioretinopathy associated with a retinal pigment epithelium aperture.
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