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MTPpilot: An Interactive Software for Visualization of Next-Generation Sequencing Results in Molecular Tumor Boards
Abdullah Kahraman1,2, Fabian M Arnold1, Jacob Hanimann1
1Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
JCO Clinical Cancer Informatics
|August 25, 2022
Summary
Molecular tumor boards can now better discuss next-generation sequencing (NGS) results with MTPpilot. This webservice integrates databases and visualization tools to assess genomic alterations and guide cancer treatment decisions.
Area of Science:
- Oncology
- Bioinformatics
- Genomics
Background:
- Comprehensive targeted next-generation sequencing (NGS) panels are standard in molecular cancer diagnostics.
- Molecular tumor boards discuss genomic alterations to determine patient cancer treatment options.
- Text-based reporting of complex NGS panel results complicates clinical discussions.
Purpose of the Study:
- To develop a webservice supporting the clinical discussion of NGS results at molecular tumor boards.
- To facilitate the assessment of functional impacts of genomic alterations.
Main Methods:
- Developed the Molecular Tumor Profiling pilot (MTPpilot) webservice.
- Utilized HTML, PHP, JavaScript, and MySQL for development.
- Integrated public genome, network, and cancer mutation databases.
Main Results:
- MTPpilot integrates diverse databases and interactive visualization tools.
- The webservice aids in assessing the functional impact of mutations.
- Supports clinical decision-making processes in tumor boards.
Conclusions:
- MTPpilot is specifically designed for discussing NGS gene panel results in molecular tumor boards.
- The webservice is freely accessible online.
- Aims to enhance the efficiency and effectiveness of molecular tumor board discussions.
