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Sequence Variation in Caprine KRTAP6-2 Affects Cashmere Fiber Diameter
Jian Cao1, Jiqing Wang1, Huitong Zhou2
1Gansu Key Laboratory of Herbivorous Animal Biotechnology, Faculty of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
Animals : an Open Access Journal From MDPI
|August 26, 2022
Summary
Researchers identified the KRTAP6-2 gene in cashmere goats, finding genetic variations linked to cashmere fiber diameter. This discovery offers a potential molecular marker for improving cashmere quality.
Area of Science:
- Animal Genetics
- Textile Science
- Molecular Biology
Background:
- Keratin-associated proteins (KAPs) are crucial for cashmere fiber structure and quality.
- The KRTAP6-2 gene, known in sheep, was previously uncharacterized in goats.
Purpose of the Study:
- To identify and characterize the KRTAP6-2 gene in goats.
- To investigate genetic variations within KRTAP6-2 and their association with cashmere fiber traits.
Main Methods:
- Gene identification via sequence analysis of goat chromosome 1.
- Polymerase chain reaction (PCR) amplification and single-strand conformation polymorphism (SSCP) analysis.
- SNP and sequence variation analysis in 230 Longdong cashmere goats.
Main Results:
- A 252-bp open reading frame similar to ovine KRTAP6-2 was identified in goats.
- Five distinct sequences (A-E) were found, revealing 11 SNPs, a 3-nucleotide variation, and a 12-bp indel.
- Variant D was significantly associated with reduced mean fiber diameter (MFD).
Conclusions:
- The KRTAP6-2 gene is present in goats and exhibits genetic diversity.
- Variations in KRTAP6-2 influence cashmere fiber diameter.
- KRTAP6-2 variants can serve as molecular markers for enhancing cashmere fiber quality.
Keywords:
KRTAP6-2cashmeregoatkeratin-associated protein 6-2 (KAP6-2)mean fiber diameter (MFD)variationMore Related Videos
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