The Hypercoagulable Profile of Patients with Bone Tumors: A Pilot Observational Study Using Rotational...

Area of Science:

• Oncology
• Hematology
• Surgical Pathology

Background:

• Malignancy-associated coagulopathy (MAC) in bone tumor patients requires detailed evaluation for effective thromboprophylaxis.
• Perioperative hemostatic changes in surgical patients with bone tumors are not fully understood with conventional testing.

Purpose of the Study:

• To assess perioperative hemostatic changes in bone tumor patients undergoing oncologic resection.
• To compare conventional coagulation tests with rotational thromboelastometry (ROTEM) in this patient group.

Main Methods:

• Observational study including 50 bone tumor patients and 30 healthy controls.
• Preoperative and postoperative coagulation evaluation using conventional tests and ROTEM analysis.
• Comparison of coagulation parameters between tumor patients and controls.

Main Results:

• Conventional coagulation tests showed no significant differences between groups.
• ROTEM analysis revealed lower CT and CFT, higher A10 and MCF, and elevated LI60 in bone tumor patients, indicating a hypercoagulable state.
• Multiple linear regression confirmed an independent association between bone tumors and these hemostatic changes.

Conclusions:

• ROTEM is advantageous over conventional tests for detecting subtle hemostatic profile changes in bone tumor patients.
• The hypercoagulable state in bone tumors is attributed to malignancy-associated coagulation cascade activation, platelet activation, and hypofibrinolysis.