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Related Experiment Videos

Diurnal responsiveness to apomorphine.

S T Gancher, J G Nutt

    Neurology
    |July 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Parkinson's patients may experience better L-dopa response in the morning. However, studies on apomorphine suggest no significant diurnal changes in dopaminergic receptor responsiveness in Parkinson's disease.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Movement Disorders

    Background:

    • Parkinson's disease is characterized by motor symptoms often fluctuating with medication response.
    • Patients frequently report better levodopa (L-dopa) efficacy in the morning.
    • This suggests potential diurnal variations in dopaminergic system responsiveness.

    Purpose of the Study:

    • To investigate diurnal fluctuations in dopaminergic receptor responsiveness in Parkinson's disease.
    • To compare the effects of apomorphine administered in the morning versus the afternoon.

    Main Methods:

    • Nine fluctuating Parkinson's patients were administered subcutaneous apomorphine during "off" periods.
    • Apomorphine was given in both morning and afternoon sessions.
    • Response duration, magnitude, and area under the time-response curve were analyzed.

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    Main Results:

    • Apomorphine response duration and area under the curve were dose-dependent.
    • No significant difference was found in response duration to the same apomorphine dose between morning and afternoon.
    • Three patients responded only to the afternoon dose at threshold levels.

    Conclusions:

    • The study suggests no substantial diurnal change in striatal dopaminergic responsiveness in Parkinson's disease.
    • Observed L-dopa timing effects may not be solely due to receptor sensitivity fluctuations.
    • Further research is needed to understand the complex L-dopa response patterns.