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Recent Advances and Challenges in Cancer Immunotherapy

Chelsea Peterson1, Nathan Denlinger1, Yiping Yang1

  • 1Division of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.

Cancers
|August 26, 2022
PubMed

Cancer immunotherapy has revolutionized the field of oncology in recent years. Harnessing the immune system to treat cancer has led to a large growth in the number of novel immunotherapeutic strategies, including immune checkpoint inhibition, chimeric antigen receptor T-cell therapy and cancer vaccination. In this review, we will discuss the current landscape of immuno-oncology research, with a focus on elements that influence immunotherapeutic outcomes. We will also highlight recent advances in basic aspects of tumor immunology, in particular, the role of the immunosuppressive cells within the tumor microenvironment in regulating antitumor immunity. Lastly, we will discuss how the understanding of basic tumor immunology can lead to the development of new immunotherapeutic strategies.

Keywords:
cancer vaccinechimeric antigen receptor (CAR)-T cell therapyimmune checkpoint inhibitorimmunotherapyneoantigentumor microenvironment (TME)tumor-associated macrophages (TAMs)

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