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ASPN Is a Potential Biomarker and Associated with Immune Infiltration in Endometriosis
1Department of Gynecology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Genes
|August 26, 2022
Summary
Asprosin (ASPN) is upregulated in endometriosis and linked to immune cell infiltration. This biomarker shows diagnostic potential and may offer a new target for endometriosis immunotherapy.
Area of Science:
- Gynecology and Immunology
- Molecular Biology and Biomarker Discovery
Background:
- Endometriosis is a benign gynecological disease with abnormal immune cell activity in lesions.
- Identifying reliable biomarkers and understanding the immune microenvironment are crucial for endometriosis management.
Purpose of the Study:
- To identify novel biomarkers for endometriosis.
- To investigate the relationship between Asprosin (ASPN) expression and the endometriosis immune microenvironment.
Main Methods:
- Utilized Gene Expression Omnibus (GEO) datasets (GSE141549, GSE7305) for differential gene expression analysis.
- Employed machine learning (Lasso, GLMs) for biomarker screening and validation via qRT-PCR and western blot.
- Analyzed immune cell infiltration using MCP-counter and correlated biomarker expression with immune checkpoints.
Main Results:
- Identified six potential biomarkers, with ASPN showing significant upregulation in endometriosis tissues.
- ASPN expression correlated with clinical features (r-AFS stage, age, lesion location) and was an independent risk factor.
- ASPN positively correlated with T-cell, B-cell, and fibroblast infiltration, and immune checkpoint gene expression, while negatively correlating with cytotoxic lymphocytes and NK cells.
Conclusions:
- Elevated ASPN expression is associated with altered immune cell infiltration in endometriosis.
- ASPN serves as a promising diagnostic biomarker for endometriosis.
- ASPN represents a potential target for novel immunotherapeutic strategies in endometriosis.
