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Updated: Aug 30, 2025
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A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
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Single Nucleotide Polymorphisms in COX2 Is Associated with Persistent Primary Tooth and Delayed Permanent Tooth
Erika Calvano Küchler1,2, Suelyn Danielle Henklein3, Peter Proff1
1Department of Orthodontics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.
Summary
Genetic variations in the COX2 gene are linked to persistent primary teeth (PPT) in children. Specific single nucleotide polymorphisms (SNPs) in COX2 may increase the likelihood of delayed permanent tooth eruption.
Area of Science:
- Genetics and Dental Development
- Molecular Biology and Oral Health
Background:
- Persistent primary tooth (PPT) is a common condition where baby teeth are retained beyond their normal shedding time.
- The exact causes of PPT are not fully understood, but genetic factors are suspected to play a role.
Purpose of the Study:
- To investigate the association between single nucleotide polymorphisms (SNPs) in the COX2 gene and the occurrence of PPT.
- To determine if specific COX2 gene variants influence the timing of permanent tooth eruption.
Main Methods:
- Screened 100 children undergoing orthodontic treatment for PPT using orthopantomographs (Nolla staging).
- Collected saliva samples for DNA extraction and performed real-time PCR to analyze two COX2 SNPs: rs689466 and rs5275.
- Utilized chi-square and haplotype analyses to compare allele and genotype distributions between cases (PPT) and controls.
Main Results:
- The genotype distribution of SNP rs5275 in the COX2 gene was significantly associated with PPT (p = 0.006).
- Individuals with the TT genotype for rs5275 had nearly three times the odds of presenting with PPT (p = 0.012; OR = 2.99).
- A specific haplotype (C-A for rs5275 and rs689466) was also significantly associated with PPT (p = 0.042).
Conclusions:
- Single nucleotide polymorphisms within the COX2 gene are associated with persistent primary tooth.
- These genetic variations may contribute to the delay in permanent tooth eruption, impacting dental development.
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