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Current Options and Future Perspectives in the Treatment of Dyslipidemia

Saverio Muscoli1, Mihaela Ifrim1, Massimo Russo1

  • 1Division of Cardiology, "Tor Vergata" University Hospital, v.le Oxford 81, 00133 Rome, Italy.

Journal of Clinical Medicine
|August 26, 2022
PubMed

Insights

New drugs offer hope for managing dyslipidemia when statins are insufficient. This review explores novel cholesterol-lowering therapies and alternative treatments for cardiovascular disease prevention.

Area of Science:

  • Cardiology
  • Pharmacology
  • Metabolic Diseases

Background:

  • Low-density lipoprotein cholesterol (LDL-C) is integral to atherosclerosis development.
  • Statin therapy is standard for LDL-C reduction but has limitations in efficacy and tolerability.
  • Cardiovascular disease (CVD) remains a significant health burden, necessitating advanced treatment strategies.

Purpose of the Study:

  • To review emerging pharmacological agents for dyslipidemia treatment.
  • To discuss the current status and future prospects of novel lipid-lowering drugs.
  • To explore alternative therapies for dyslipidemia and their clinical relevance.

Main Methods:

  • Narrative review of recent literature on dyslipidemia treatments.
  • Analysis of approved and investigational drugs beyond statins.
  • Examination of new therapeutic approaches for triglyceride management and familial hypercholesterolemia (FH).

Main Results:

  • Several new cholesterol-lowering drugs have been approved, expanding treatment options.
  • Promising results from ongoing clinical and preclinical trials indicate future therapeutic advancements.
  • Novel strategies are emerging for managing hypertriglyceridemia and familial hypercholesterolemia.

Conclusions:

  • The pharmacological landscape for dyslipidemia is rapidly evolving beyond statins.
  • New drugs and alternative therapies are crucial for achieving optimal lipid targets and reducing CVD risk.
  • Future research and clinical application of these advancements hold significant promise for patient outcomes.

Keywords:
ANGPTL3 inhibitorsLXR agonistsPCSK9 inhibitorsPPARβ/δbempedoic aciddyslipidemiainclisiranlomitapidemipomersenvolanesorsen

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