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Updated: Aug 30, 2025

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Trust-Based Decision-Making in the Health Context Discriminates Biological Risk Profiles in Type 1 Diabetes.

Helena Jorge1,2, Isabel C Duarte1, Carla Baptista3

  • 1Coimbra Institute for Biomedical Imaging and Translational Research, CIBIT/ICNAS, Faculty of Medicine, University of Coimbra, 3004-531 Coimbra, Portugal.

Journal of Personalized Medicine
|August 26, 2022
PubMed
Summary
This summary is machine-generated.

Individual risk preferences in social decision-making are context-dependent. Patients with preserved glycemic control exhibit adaptive choices in economic and health trust games, unlike those with poor control.

Keywords:
context-dependent trust gamediabetes type 1human decision-makingmetabolic controlnorm violationprobabilistic learningtreatment adherence

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Area of Science:

  • Neuroeconomics
  • Behavioral Economics
  • Health Decision-Making
  • Chronic Disease Management

Background:

  • Theoretical models suggest risk preferences vary with context in social decision-making.
  • Experimental investigation of decision-making models in dyadic health interactions is lacking.
  • Economic utility models and behavioral games offer frameworks for studying probabilistic learning.

Purpose of the Study:

  • To model an economic trust game within the context of Type 1 Diabetes.
  • To experimentally investigate decision-making and risk preferences in both economic and health domains.
  • To link biological profiles to adaptive/non-adaptive choice behavior in chronic disease patients.

Main Methods:

  • Ninety-one patients with Type 1 Diabetes participated in experimental trust games.
  • Games were conducted in both economic and health settings.
  • Participants completed multiple self-report questionnaires for characterization.

Main Results:

  • Patients could accurately infer payoff contingencies in the trust games.
  • Patients with preserved glycemic control demonstrated adaptive choice behavior across both domains.
  • Patients with poor glycemic control exhibited non-adaptive choices in both economic and health contexts.

Conclusions:

  • Decision-making in health and economic contexts is influenced by biological profiles.
  • Findings translate neuroeconomic principles to health decision-making and biological risk.
  • Individual decision-making under uncertainty generalizes across different contextual domains.