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Orally Dispersible Dosage Forms for Paediatric Use: Current Knowledge and Development of Nanostructure-Based
Andreea Cornilă1, Sonia Iurian1, Ioan Tomuță1
1Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, 41 V. Babes Street, 400012 Cluj-Napoca, Romania.
Pharmaceutics
|August 26, 2022
Summary
Developing nanostructure-enhanced orodispersible dosage forms can overcome taste and bioavailability challenges in pediatric medicines. This approach ensures safer, more stable, and acceptable drug products for children.
Area of Science:
- Pharmaceutical Sciences
- Nanotechnology
- Pediatric Drug Delivery
Background:
- Paediatric populations face challenges with existing medicines, including inaccurate dosing, poor stability, and low acceptability.
- Orodispersible dosage forms offer an alternative to liquids but struggle with unpleasant taste and low oral bioavailability of active pharmaceutical ingredients (APIs).
Purpose of the Study:
- To explore the potential of nanostructures to improve paediatric orodispersible dosage forms.
- To address limitations such as poor palatability and reduced API oral bioavailability.
Main Methods:
- Formation and functionalisation of various nanostructures using diverse materials.
- Incorporation of these nanostructures into orodispersible dosage forms.
Main Results:
- Nanostructures offer solutions to overcome taste masking and enhance oral bioavailability of APIs.
- The developed nanostructure-loaded orodispersible forms demonstrated potential for improved paediatric drug delivery.
Conclusions:
- Nanostructure technology can create safe, stable, and acceptable orodispersible medicines for paediatric use.
- This innovative approach addresses critical unmet needs in paediatric pharmacotherapy.
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