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Development of Alectinib-Suspended SNEDDS for Enhanced Solubility and Dissolution
Eun Ji Park1, Seung Ah Choi1, Kyoung Ah Min1
1College of Pharmacy and Inje Institute of Pharmaceutical Sciences and Research, Inje University, Gimhae 50834, Korea.
Pharmaceutics
|August 26, 2022
Summary
This study developed a novel suspended self-nanoemulsifying drug delivery system (Su-SNEDDS) for alectinib hydrochloride (ALH). The Su-SNEDDS significantly enhanced ALH solubility and dissolution rates, offering a promising oral dosage form.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Nanotechnology
Background:
- Alectinib hydrochloride (ALH) is a BCS class IV drug with poor water solubility.
- Enhancing ALH solubility and dissolution is crucial for effective oral delivery.
Purpose of the Study:
- To develop a novel suspended self-nanoemulsifying drug delivery system (Su-SNEDDS) for ALH.
- To improve the solubility and dissolution rate of ALH using Su-SNEDDS.
Main Methods:
- Preparation of Su-SNEDDS using Kolliphor HS 15 and Capmul MCM C8.
- Incorporation of micronized ALH particles (<5 μm) into the SNEDDS.
- Evaluation of dispersion, particle size, and dissolution rate in SLS buffer.
Main Results:
- The optimized SNEDDS showed complete dissolution within 30 min but low ALH loading (<0.6%).
- 10% ALH-loaded Su-SNEDDS achieved a 20-fold higher loading capacity.
- Su-SNEDDS demonstrated 100% dissolution rate within 30 min with spontaneous nanoemulsion formation.
Conclusions:
- Su-SNEDDS is an effective strategy to enhance ALH solubilization and dissolution.
- The developed system offers a novel technological approach for oral delivery of poorly soluble drugs.
- Micronized ALH particles within Su-SNEDDS readily disperse and solubilize.
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