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Related Concept Videos

Redox Reactions01:24

Redox Reactions

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Oxidation-reduction or redox reactions involve the transfer of electrons from one molecule or atom to another. When an atom gains an electron, another atom must lose an electron, meaning oxidation and reduction must occur together. Since the redox occurs in pairs, the atom that gets oxidized is also called the reducing agent or reductant, and the atom that is reduced is also called the oxidizing agent or oxidant. A straightforward way to remember the definitions of oxidation and reduction is...
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Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
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Redox-Responsive Polymersomes as Smart Doxorubicin Delivery Systems.

Carmen Ferrero1, Marta Casas1, Isidoro Caraballo1

  • 1Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, C/Prof. García González No. 2, 41012 Sevilla, Spain.

Pharmaceutics
|August 26, 2022
PubMed
Summary

Redox-responsive polymersomes efficiently encapsulate doxorubicin hydrochloride (Dox·HCl) for controlled anticancer drug delivery. These smart nanocarriers release drugs selectively in the tumor microenvironment, enhancing therapeutic efficacy.

Keywords:
doxorubicin hydrochloridedrug release kineticspolymersomeredox-responsivesmart drug delivery systemstriblock copolymer mPEG–PDH–mPEG

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery

Background:

  • Stimuli-responsive polymersomes offer programmed release of cytotoxic anticancer agents like doxorubicin hydrochloride (Dox·HCl).
  • A novel biodegradable, redox-responsive triblock copolymer (mPEG-PDH-mPEG) with disulfide linkages was developed.

Purpose of the Study:

  • To develop and characterize polymersomes for simultaneous formation and doxorubicin hydrochloride loading using a solvent-exchange method.
  • To evaluate the drug encapsulation efficiency and in vitro release profile of the designed polymersomes.

Main Methods:

  • Synthesis of mPEG-PDH-mPEG triblock copolymer.
  • Solvent-exchange method for polymersome formation and doxorubicin hydrochloride loading.
  • Characterization of polymersome morphology, size, zeta potential, encapsulation efficiency, and drug release kinetics.

Main Results:

  • Uniform spherical polymersomes (120-190 nm) with negative zeta potentials were successfully prepared.
  • High encapsulation efficiency of doxorubicin hydrochloride (up to 98 wt.%) was achieved.
  • Prolonged, diffusion-driven drug release (~34% in 48 h) at physiological conditions was observed, with enhanced release (~77%) in the presence of glutathione (GSH) due to disulfide bond cleavage.

Conclusions:

  • The designed redox-responsive polymersomes demonstrate excellent potential for controlled and selective delivery of doxorubicin hydrochloride.
  • These smart nanocarriers are promising for targeted drug release in the reductive environment characteristic of cancer cells.