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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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Tablet coating is a critical pharmaceutical process enhancing oral dosage forms. This review covers polymers, processes, and computational modeling for optimizing film coating uniformity and quality.

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Area of Science:

  • Pharmaceutical Technology
  • Materials Science

Background:

  • Tablet coating is a common yet critical process for oral solid dosage forms.
  • It enhances drug delivery, meets clinical needs, and adds value to pharmaceutical products.

Purpose of the Study:

  • To review film coating processes and polymers used in solid dosage forms.
  • To highlight the importance of coating uniformity and technological advancements.

Main Methods:

  • Review of existing literature on tablet coating techniques (solvent-based and solvent-free).
  • Discussion of computational modeling and experimental evaluation for process optimization.
  • Focus on polymers, coating equipment, and evaluation methods.

Main Results:

  • Different coating techniques offer advantages and disadvantages, requiring continuous modification.
  • Inter- and intra-batch uniformity of coating is crucial for product quality, especially for medicated coatings.
  • Computational modeling and experimental evaluation aid in optimizing operational parameters, saving time and cost.

Conclusions:

  • Film coating significantly impacts the characteristics and efficacy of oral solid dosage forms.
  • Advancements in coating technology, materials, and evaluation are essential for pharmaceutical innovation.
  • Optimized coating processes ensure product quality and therapeutic effectiveness.