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Formulation and Physicochemical Characterization of Capecitabine-Loaded Cubosomes for Enhanced Drug Delivery System
1Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, 45142, Saudi Arabia.
Drug Design, Development and Therapy
|March 23, 2026
Summary
This study developed topical cubosomes for capecitabine (CPB), enhancing its dermal delivery. The novel formulation showed improved drug release and permeation, offering a promising anticancer topical treatment.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Nanotechnology
Background:
- Capecitabine (CPB) is a Biopharmaceutics Classification System (BCS) Class III hydrophilic anticancer drug.
- Its hydrophilic nature poses challenges for effective dermal delivery.
- Targeted topical delivery aims to increase localized drug concentration.
Purpose of the Study:
- To develop and characterize a topical cubosomal formulation encapsulating capecitabine (CPB).
- To enhance the dermal delivery efficiency of capecitabine.
- To evaluate the potential of CPB-loaded cubosomes as an innovative targeted drug delivery system.
Main Methods:
- Cubosomal formulations were prepared using Pluronic F-68, Tween 80, and glyceryl monooleate.
- Formulations were characterized for particle size, zeta potential, morphology (SEM), and in vitro release/permeation.
- Excipient concentrations were varied to optimize the formulation.
Main Results:
- The optimized formulation had a particle size of 177.66 nm with well-segregated, nanosized cubic structures observed via SEM.
- In vitro drug release ranged from 40% to 67%.
- Permeation efficiency varied from 50% to 92%, indicating enhanced dermal transport.
Conclusions:
- CPB-loaded cubosomes exhibited favorable physicochemical properties.
- The formulation significantly improved capecitabine release and dermal permeation.
- These cubosomes show strong potential as an effective topical delivery system for capecitabine.
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