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Inactivated vaccine Covaxin/BBV152: A systematic review
Tousief Irshad Ahmed1, Saqib Rishi2, Summaiya Irshad3
1Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, JK, India.
Frontiers in Immunology
|August 26, 2022
Summary
Bharat Biotech
Area of Science:
- Virology
- Immunology
- Vaccinology
Background:
- Bharat Biotech's BBV152 (Covaxin) is an indigenous inactivated virus vaccine against SARS-CoV-2.
- A systematic review of 25 studies assessed Covaxin's efficacy, immunogenicity, and safety up to March 2022.
Approach:
- Systematic review of pre-clinical and clinical trials (Phase I-III) of BBV152 (Covaxin).
- Data analysis focused on antibody titers, T cell responses, protection against severe COVID-19, and adverse events.
Key Points:
- Covaxin demonstrated significant neutralizing and binding antibody titers with Th1-biased T cell responses.
- Phase III trials showed 93.4% efficacy against severe COVID-19 and an acceptable safety profile.
- Covaxin showed protection against Alpha, Beta, and Delta variants but limited efficacy against Omicron.
Conclusions:
- Covaxin offers significant protection against severe COVID-19 and has a favorable safety profile.
- Heterologous prime-boost vaccination strategies warrant further investigation for future variant protection.
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