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Anemia and Heart Failure: A Narrative Review
Shiza W Siddiqui1, Tejaswini Ashok2, Nassar Patni3
1Research, Dubai Medical College, Dubai, ARE.
Cureus
|August 26, 2022
Summary
Anemia in heart failure patients is common and linked to poor outcomes. Correcting anemia with iron or erythropoiesis-stimulating agents may improve quality of life, but research is limited.
Area of Science:
- Cardiology
- Hematology
- Internal Medicine
Background:
- Anemia is prevalent in heart failure (HF) patients.
- Anemia is associated with increased hospital admissions, morbidity, and mortality in HF.
- Correction of anemia can improve quality of life and clinical outcomes in HF patients.
Purpose of the Study:
- To review the multifactorial pathophysiology of anemia in heart failure.
- To discuss diagnostic guidelines for anemia in HF.
- To explore research-based management strategies for anemia in HF.
Main Methods:
- Literature review of existing research on anemia in heart failure.
- Discussion of pathophysiological mechanisms including iron deficiency, inflammation, erythropoietin (Epo) levels, and renin-angiotensin-aldosterone system (RAAS) activation.
- Analysis of current diagnostic and management guidelines.
Main Results:
- Key pathophysiological factors include iron deficiency, chronic inflammation, abnormal Epo levels, and RAAS activation.
- Management strategies primarily involve iron supplementation and erythropoiesis-stimulating agents (ESAs).
- Existing research in this area is limited and has yielded conflicting results.
Conclusions:
- Anemia in HF is complex with multiple contributing factors.
- Iron and ESAs are potential treatments, but evidence is not definitive.
- Further research is needed to clarify optimal diagnostic and management approaches for anemia in HF.
Keywords:
anaemia of chronic disease (acd)anemiacongestive heart faiulreepoheart failureiron deficiency anaemia (ida)More Related Videos
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