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Updated: Aug 30, 2025

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Metal-free aminofluorination of α-diazo 2H-benzopyran-4-one: convenient access to β-fluoramides
Wentao Zhang1,2, Minghao Sun1, Kejia You1
1State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China. mabaochun@lzu.edu.cn.
Abstract:
We have developed a convenient synthesis of a series of β-fluoramides in 65% yield. The process involved a tandem fluorination/Ritter reaction to synthesize β-fluoramides using α-diazo 2H-benzopyran-4-one compounds. Selectfluor was used as the electrophilic fluoride source in acetonitrile to build the β-fluorinated quaternary carbon center and amide derivatives of 2H-benzopyran-4-one in one step. The products N-(2-(2-fluoro-2,3-dihydro-3-oxobenzofuran-2-yl)propan-2-yl)acetamides were a series of bifunctional compounds with a 2-fluoro-2,3-dihydro-3-oxobenzofuran motif and amide groups.
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