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Updated: Aug 30, 2025

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Mini-tablets as technological strategy for modified release of morphine sulfate
Raizza Tafet Carminato E Silva1, Marcos Luciano Bruschi1
1Laboratory of Research and Development of Drug Delivery Systems, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, State University of Maringa, Maringa, Brazil.
Intelligent formulation design successfully created modified-release morphine sulfate mini-tablets. Formulation F1 demonstrated effective prolonged drug release, highlighting its potential for improved pain management.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
Background:
- Modified-release dosage forms are crucial for sustained drug delivery and improved patient compliance.
- Morphine sulfate is a potent analgesic requiring controlled release to manage pain effectively and minimize side effects.
Purpose of the Study:
- To develop and characterize mini-tablets for modified release of morphine sulfate using intelligent formulation design.
- To evaluate the in vitro drug release profiles of immediate and modified-release formulations.
- To assess the suitability of formulation F1 for prolonged morphine sulfate release.
Main Methods:
- Intelligent formulation design using Hiperstart® software to propose formulation F1.
- Preparation of three mini-tablet formulations (F1, F2, F3) for modified and immediate release.
- Characterization of powder properties (density, flowability) and mini-tablet attributes (hardness, friability, weight variation).
- In vitro drug release studies conducted using USP Apparatus 1.
Main Results:
- All formulations exhibited good powder flow properties and acceptable mini-tablet characteristics.
- Formulations F1 and F2 (modified release) demonstrated significantly slower drug release compared to F3 (immediate release).
- F3 released 90% of morphine sulfate within 10 minutes, while F1 and F2 required 240 minutes for comparable release.
Conclusions:
- Intelligent formulation design is effective for developing improved mini-tablet matrices.
- Formulation F1 is suitable for modified release of morphine sulfate, offering prolonged drug delivery.
- Further research is needed to optimize mini-tablet formulations for extended morphine sulfate release.
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