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The best of both worlds: mastering nerve regeneration combining biological and nanotechnological tools

Paula A Soto1, Marcela B Fernández van Raap2, C Patricia Setton-Avruj1

  • 1Departamento de Química Biológica, Cátedra de Química Biológica Patológica, Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica; Instituto de Química y Fisicoquímica Biológicas (IQUIFIB), Universidad de Buenos Aires, Buenos Aires, Argentina.

Neural Regeneration Research
|August 26, 2022
PubMed
Abstract

No abstract available in PubMed .

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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