Related Experiment Video
Updated: Aug 30, 2025
07:25
Author Spotlight: A Focus on Standardized Salivary Gland Ultrasound Protocol in Connective Tissue Disease Research
Published on: October 13, 2023
2.8K
The Genesis of Sjögren
George Aw Bruyn1, Priscilla Wong2
1Reumakliniek Lelystad, Het Ravelijn 1, 8233, Lelystad, BR, The Netherlands. gawbruyn@wxs.nl.
Zeitschrift Fur Rheumatologie
|August 26, 2022
Summary
Swedish ophthalmologist Henrik Sjögren described a syndrome linking dry eyes, dry mouth, and arthritis. His detailed monograph led to the recognition of this new condition, now known as Sjögren's syndrome.
Area of Science:
- Ophthalmology
- Rheumatology
- Medical History
Background:
- Henrik Sjögren, a Swedish ophthalmologist, authored a comprehensive monograph in 1933.
- His work detailed a distinct group of patients presenting with keratoconjunctivitis sicca, xerostomia, and arthritis.
Purpose of the Study:
- To highlight key biographical and professional milestones of Henrik Sjögren.
- To trace the development of his research that led to the identification of a new syndrome.
Main Methods:
- Review of historical medical literature and Sjögren's original dissertation.
- Analysis of the clinical observations documented in the monograph.
Main Results:
- The monograph described a constellation of symptoms: dry eyes (keratitis sicca), dry mouth (xerostomia), and joint inflammation (arthritis).
- Sjögren's meticulous documentation provided the foundation for recognizing these interconnected symptoms as a distinct clinical entity.
Conclusions:
- Henrik Sjögren's work was pivotal in delineating a new systemic autoimmune condition.
- His research laid the groundwork for the future understanding and diagnosis of Sjögren's syndrome.
Keywords:
Academic dissertationCanon of rheumatologyHenrik SjögrenHistory of medicineSjögren’s syndromeMore Related Videos
Related Concept Videos
01:17Gastritis-II: Pathophysiology
494
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
494
01:29Autoimmune Disorders
630
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
630
01:24Nephrotic Syndrome I : Introduction
21
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
21
01:23Cystic Fibrosis: Pathogenesis
348
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
348
01:29Biological Causes of Schizophrenia
133
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
133
01:23Salivary Glands and Saliva
887
The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
887