Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lymphocyte numbers in endogenous depression.

D Murphy, R Gardner, J F Greden

    Psychological Medicine
    |May 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A proof of concept case series of botulinum toxin a treatment for ischemic feet due to Raynaud's phenomenon.

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2026
    Same author

    Sulodexide in venous disease.

    Journal of thrombosis and haemostasis : JTH·2018
    Same author

    A genome-wide association study of antidepressant response in Koreans.

    Translational psychiatry·2015
    Same author

    Clinical science and biomarkers: against RDoC.

    Acta psychiatrica Scandinavica·2015
    Same author

    A genome-wide association study of antidepressant response in Koreans.

    Translational psychiatry·2015
    Same author

    Association of the choline acetyltransferase gene with responsiveness to acetylcholinesterase inhibitors in Alzheimer's disease.

    Pharmacopsychiatry·2015

    Patients with depression, particularly unipolar depression, often show reduced lymphocyte counts. This immune abnormality was more prevalent in unipolar patients compared to bipolar patients, suggesting distinct biological underpinnings.

    Area of Science:

    • Immunology
    • Psychiatry
    • Endocrinology

    Background:

    • Depression is associated with various physiological changes.
    • Lymphocyte counts can be affected by stress and hormonal imbalances.

    Purpose of the Study:

    • To investigate differences in blood lymphocyte counts between unipolar and bipolar depression.
    • To explore the relationship between lymphocyte counts and dexamethasone suppression test (DST) response in depressed patients.

    Main Methods:

    • Blood counts of 80 depression patients (50 unipolar, 30 bipolar) were analyzed.
    • Lymphocyte subsets (relative and absolute counts) were quantified.
    • DST response was assessed and correlated with lymphocyte levels.

    Main Results:

    Related Experiment Videos

    • Reduced circulating lymphocyte numbers were observed in a significant portion of depressed patients.
    • This lymphopenia was more common in unipolar depression (52%) than bipolar depression (27%).
    • Unipolar patients with abnormal DST responses exhibited significantly lower lymphocyte counts compared to bipolar patients.

    Conclusions:

    • Unipolar depression is characterized by a higher prevalence of lymphopenia compared to bipolar depression.
    • Abnormal cortisol regulation, suggested by DST, may contribute to reduced lymphocyte counts, but further research is needed for full explanation.