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On the meta-analysis of hormetic effects
1Department of Ecology, School of Applied Meteorology, Nanjing University of Information Science & Technology, Nanjing 210044, Jiangsu, People's Republic of China.
The Science of the Total Environment
|August 26, 2022
Summary
Evidence for hormetic responses at sub-no-observed-adverse-effect-level (sub-NOAEL) doses is growing. This work proposes a standardized protocol for robust meta-analyses of these chemical effects across studies.
Area of Science:
- Toxicology
- Environmental Health
- Pharmacology
Background:
- Growing evidence suggests hormetic responses occur at sub-no-observed-adverse-effect-level (sub-NOAEL) doses.
- Meta-analyses are needed to synthesize findings on sub-NOAEL chemical effects.
- Current meta-analysis methods are not standardized for hormetic responses.
Approach:
- Proposes a protocol for literature searches using holistic keywords.
- Defines methods for identifying control groups and NOAEL.
- Includes selection of response indicators and considers dose-response variations.
Key Points:
- Standardized methodology for meta-analyzing sub-NOAEL hormetic effects is lacking.
- Protocol addresses keyword selection, control designation, and NOAEL identification.
- Incorporates response indicators, time, and dose as variables.
Conclusions:
- The proposed protocol offers a harmonized approach for meta-analyzing sub-NOAEL chemical effects.
- A robust methodology is crucial for understanding hormetic dose-response relationships.
- This guideline will aid researchers in synthesizing data on low-dose chemical impacts.
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