Related Experiment Video
Updated: Aug 30, 2025

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients
Published on: September 20, 2020
Thoracic Duct Embolization Using Transabdominal Antegrade and Transcervical Retrograde Accesses
Daniel Crawford1, Carlos J Guevara1, Seung Kwon Kim1
1Division of Interventional Radiology, Mallinckrodt Institute of Radiology, Washington University St. Louis School of Medicine, St. Louis, Missouri.
Insights
Thoracic duct embolization (TDE) for chyle leaks shows good clinical success. Transabdominal antegrade access is more technically successful than transcervical retrograde access, but retrograde TDE aids complex cases.
Area of Science:
- Interventional Radiology
- Vascular Surgery
- Gastroenterology
Background:
- Chyle leaks, often resulting from iatrogenic causes or spontaneous events, pose significant clinical challenges.
- Thoracic duct embolization (TDE) is an interventional technique used to manage chyle leaks.
Purpose of the Study:
- To evaluate the technical success and clinical outcomes of TDE.
- To compare transabdominal antegrade and transcervical retrograde access methods for TDE.
Main Methods:
- Retrospective chart review of 99 patients undergoing 113 TDE procedures over 6 years.
- Analysis of technical success rates for transabdominal antegrade and transcervical retrograde TDE.
- Assessment of overall clinical success and adverse events.
Main Results:
- Overall technical success rate for TDE was 77%.
- Transabdominal antegrade access had a 68% technical success rate; transcervical retrograde access had a 44% success rate.
- Clinical success (chyle leak resolution) was achieved in 83% of patients, with 8 SIR-classified adverse events.
Conclusions:
- Transabdominal antegrade access offers higher technical success for TDE.
- Transcervical retrograde access, though challenging, improves outcomes in cases of thoracic duct occlusion or small anatomy.
- TDE is an effective treatment for chyle leaks, with combined approaches enhancing success rates.
Purpose:
To evaluate the technical success and clinical outcomes of thoracic duct embolization (TDE) using transabdominal antegrade and transcervical retrograde accesses to treat patients with chyle leak.
Materials And Methods:
This study was a retrospective, nonblinded, single-institution chart review of all patients aged 18 years or older over a 6-year time frame who underwent lymphangiography with attempted TDE for iatrogenic or spontaneous chyle leaks using transabdominal antegrade and/or transcervical retrograde accesses.
Results:
Ninety-nine patients underwent 113 procedures. Eighty-five patients underwent 1 procedure, and 14 patients required 2 procedures. The technical success rate of TDE was 68% (72/106) with transabdominal antegrade access and 44% (15/34) with transcervical retrograde access. The overall technical success rate of TDE, including both the access methods, was 77% (87/113). The most common reasons for transabdominal access failure were small caliber of the cisterna chyli and thoracic duct (TD) occlusion. Five patients were lost to follow-up. Overall clinical success, defined as resolution of the chyle leak, was achieved in 83% (78/94) of the patients. There were 6 Society of Interventional Radiology (SIR) level 1 adverse events (AEs), 5 SIR level 2 AEs, and 2 SIR level 3 AEs. Nontarget embolization occurred in 2 patients.
Conclusions:
Although transcervical retrograde TDE is a challenging procedure, with a lower technical success rate than transabdominal antegrade access, retrograde access improved the technical and clinical success rates of the treatment of chyle leaks in cases of thoracic duct occlusion, small cisterna chyli, and leaks located in the abdomen.
More Related Videos
Related Concept Videos
Endoscopic Studies II: Thoracocentesis
Description
Excess pleural fluid or air may accumulate in some respiratory disorders in the thoracic cavity. To treat pleural effusion, a physician conducts thoracentesis by carefully piercing the chest wall and entering...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Veins of Thorax
The azygos vein, positioned just right of the midline and anterior to the vertebral column, begins at the junction of the right ascending lumbar and subcostal veins, terminating in the superior vena cava. This vein drains blood from the right side of the thoracic wall, thoracic viscera, and posterior abdominal wall.
The...
Venous Thrombosis III: Interprofessional Care
Lymphatic Vessels and Lymph Transport
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...

