Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Radiation: Applications01:17

Radiation: Applications

The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-institutional Comparison of Novel O-ring Linac Cone Beam Computed Tomography with Fan Beam Computed Tomography.

Journal of medical physics·2026
Same author

Tunneling through 100 Years of Quantum Mechanics: An ACS Collection to Celebrate the Centennial.

ACS applied materials & interfaces·2025
Same author

Anatomical Considerations for Endovascular Penile Interventions.

Seminars in interventional radiology·2025
Same author

Anatomical Considerations for Biliary Interventions: Navigating Challenging Cases.

Seminars in interventional radiology·2025
Same author

Reflecting on the Past Year.

Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners·2025
Same author

Direct-to-Treatment Adaptive Radiation Therapy: Live Planning of Spine Metastases Using Novel Cone Beam Computed Tomography.

International journal of radiation oncology, biology, physics·2025

Related Experiment Video

Updated: Jun 18, 2026

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System
08:25

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

15.8K

Control-point-specific plan robustness in volumetric modulated arc therapy-based cranial radiotherapy.

Daniel Crawford1, Cody Church2, Robert Lee MacDonald1,3,4

  • 1Department of Physics and Atmospheric Science, Dalhousie University, Halifax, Nova Scotia, Canada.

Journal of Applied Clinical Medical Physics
|January 2, 2026
PubMed
Summary

Identifying motion-sensitive control points in radiotherapy can mitigate intrafraction motion effects. Targeting these specific points may improve plan robustness and reduce planning target volume (PTV) margins.

Keywords:
DVHVMATcontrol pointcranial radiotherapyintrafraction motionplan robustness

More Related Videos

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.9K
Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant
05:18

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant

Published on: October 6, 2023

1.8K

Related Experiment Videos

Last Updated: Jun 18, 2026

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System
08:25

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

15.8K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.9K
Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant
05:18

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant

Published on: October 6, 2023

1.8K

Area of Science:

  • Radiation Oncology
  • Medical Physics
  • Radiotherapy Planning

Background:

  • Intrafraction patient motion can degrade radiotherapy plan quality.
  • Identifying motion-sensitive control points is crucial for mitigating these effects.
  • Robust planning strategies aim to improve dosimetry and reduce planning target volume (PTV) margins.

Purpose of the Study:

  • To enhance radiotherapy plan robustness against intrafraction motion by identifying control-point-specific dosimetric sensitivities.
  • To retrospectively assess the impact of simulated patient motion on cranial radiotherapy plans.
  • To explore control-point-specific plan characteristics influencing dosimetry.

Main Methods:

  • Thirty cranial volumetric modulated arc therapy (VMAT) plans were converted to static field plans.
  • Simulated intrafraction motion traces (n=100) were applied using a MATLAB application.
  • Planning target volume (PTV) coverage and gross tumor volume (GTV) dose metrics were analyzed; control point dose-volume histograms (DVHs) were assessed using area under the curve (AUC) analysis.

Main Results:

  • Simulated intrafraction motion led to PTV coverage loss in 78.6% of motion traces, with no significant changes in GTV D99%.
  • Multileaf collimator (MLC) aperture areas showed weak to moderate correlations with standard deviation of AUC (sAUC).
  • Two distinct subpopulations of MLC aperture areas were identified based on mean AUC (mAUC) thresholds.

Conclusions:

  • The dosimetric impact of intrafraction motion is linked to the sensitivity of specific control points.
  • Targeting motion-sensitive control points for gating could improve robustness and dosimetry, supporting PTV margin reduction.
  • Cranial radiotherapy plans are suitable for control-point-level motion analysis, with potential expansion to other anatomical sites.