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Related Experiment Video

Updated: Aug 30, 2025

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

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Published on: December 15, 2014

Apparent Diffusion Coefficient Reproducibility Across 3 T Scanners in a Breast Diffusion Phantom.

Lauren K Fang¹, Kathryn E Keenan², Michael Carl³

¹Department of Radiology, University of California-San Diego, La Jolla, California, USA.

Journal of Magnetic Resonance Imaging : JMRI

|August 27, 2022

Summary

This summary is machine-generated.

Normalization of diffusion-weighted MRI (DW-MRI) metrics using an internal reference significantly improved accuracy and reduced variability across scanners. Higher-resolution protocols provided more reproducible apparent diffusion coefficients (ADCs) than standard protocols.

Keywords:

apparent diffusion coefficient breast MRI breast phantom diffusion reproducibility

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Last Updated: Aug 30, 2025

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In Situ Monitoring of Diffusion of Guest Molecules in Porous Media Using Electron Paramagnetic Resonance Imaging

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Published on: September 2, 2016

Area of Science:

Medical Imaging
Biophysics
Radiology

Background:

Diffusion-weighted MRI (DW-MRI) metrics have limited reported accuracy and variability data across diverse scanner and protocol combinations.
Understanding reproducibility is crucial for clinical adoption of DW-MRI.

Purpose of the Study:

Evaluate DW-MRI estimate reproducibility across multiple scanners and protocols.
Assess the impact of 8-channel vs. 16-channel breast coils on DW-MRI metrics in a phantom.

Main Methods:

A breast phantom with varying polyvinylpyrrolidone (PVP) concentrations was used.
Three DW-MRI single-shot echo planar imaging protocols at 3T were tested across multiple scanners.
Apparent diffusion coefficients (ADCs) were assessed for accuracy and variability, with normalization to an internal water reference.

Main Results:

Normalization to an internal water reference improved ADC accuracy (2% vs. 11%) and reduced interscanner variability (4% vs. 7%).
Higher-resolution DW-MRI protocols showed less interscanner variability (6%) compared to clinical protocols (9%).
Both 8-channel and 16-channel breast coils demonstrated similar accuracy and precision.

Conclusions:

Internal reference normalization enhances interscanner ADC reproducibility in DW-MRI.
High-resolution DW-MRI protocols offer improved accuracy and reduced variability compared to standard clinical protocols.
Coil channel number has minimal impact on DW-MRI accuracy and precision.