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Related Experiment Video

Updated: May 29, 2026

Ultrasound Tissue Characterization of Human Achilles Tendon by Stability Quantification of Echo Patterns
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Ultrasound Tissue Characterization of Human Achilles Tendon by Stability Quantification of Echo Patterns

Published on: September 5, 2025

Quantitative Ultrashort Echo-Time MRI to Assess In Vivo Rotator Cuff Tendon Quality.

Misung Han1, Peder E Z Larson1,2, Thomas M Link1

  • 1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
|May 28, 2026
PubMed
Summary

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Quantitative ultra-short echo-time (UTE) MRI methods accurately assess rotator cuff tendon quality. These advanced imaging biomarkers, including T2*m and MMF, correlate with clinical outcomes and surgical results.

Area of Science:

  • Musculoskeletal Imaging
  • Biomaterials Science
  • Orthopedic Surgery

Background:

  • Rotator cuff tears cause significant pain and disability.
  • Conventional MRI cannot objectively assess tendon degeneration.
  • Objective assessment of tendon quality is crucial for surgical success.

Purpose of the Study:

  • Develop and evaluate quantitative ultra-short echo-time (UTE) MRI methods.
  • Assess rotator cuff tendon quality in vivo.
  • Correlate quantitative MRI metrics with clinical outcomes.

Main Methods:

  • Utilized multi-echo UTE Cones and MT-prepared UTE Cones sequences.
  • Performed mono-exponential and bi-exponential fitting for T2* parameters (T2*m, T2*s, T2*l, fs).
  • Included bovine tendons, volunteers, patients, and healthy controls; obtained outcome measures.
Keywords:
degenerationquantitative UTErotator cuff tendontendon qualitytendon tears

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Last Updated: May 29, 2026

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Main Results:

  • Quantitative UTE MRI metrics (T2*m, fs, MMF) differed significantly between patients and controls.
  • T2*m and MMF showed moderate correlations with outcome measures (|r| ≤ 0.63).
  • Higher pathological severity correlated with increased T2*m and decreased MMF.

Conclusions:

  • Quantitative UTE MRI biomarkers (T2*m, MMF) are sensitive to rotator cuff tendon degeneration.
  • These metrics correlate with clinical outcomes, aiding surgical decision-making.
  • UTE MRI shows potential for monitoring tendon healing post-surgery.