The role of doping strategy in nanoparticle-based electrochemiluminescence biosensing

Doping plays a crucial role in electrochemiluminescence (ECL) due to the followings: (1) Modulation of electronic structure, alteration of the surface state of nanoparticles (NPs), providing effective protection from the surrounding environment, thereby leading to ECL emitters with exceptional properties including tunable spectra, high luminescence efficiency, low excitation potential, and good stability. (2) Employment of doped NPs as promising coreactant alternatives due to the presence of functional groups such as amines induced by NP doping. (3) Serving as novel co-reaction accelerators (CRAs) for ECL through doping induced high catalytic properties. (4) Behaving as excellent carriers to load ECL emitters, recognition elements, and catalysts due to doping-induced larger surface area, higher conductivity and better biocompatibility of NPs. As a consequence, doped NPs have aroused broad interest and found wide applications in various ECL sensing platforms. In this review, the current promising improvements, concepts, and excellent applications of doped NPs for ECL biosensing are addressed. We aim to bring to light the physicochemical characteristics of various doped NPs that endow them with appealing ECL performance, leading to diverse applications in biosensing.