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Updated: Aug 30, 2025
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Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
Published on: January 5, 2024
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Blood coagulation and cancer genes
1McGill University and Research Institute of the McGill University Health Centre, Canada.
Best Practice & Research. Clinical Haematology
|August 27, 2022
Summary
Cancer-associated thrombosis (CAT) is linked to cancer cell genetics, not just tumor growth. Understanding the cancer coagulome is key to predicting and managing thrombosis in cancer patients.
Area of Science:
- Oncology
- Hematology
- Molecular Biology
Background:
- Cancer-associated thrombosis (CAT), encompassing venous thromboembolism (VTE) and arterial thromboembolism (ATE), significantly increases morbidity and mortality in cancer patients.
- Emerging evidence indicates CAT is causally linked to the molecular and genetic characteristics of cancer cells, rather than being a mere consequence of tumor progression.
Purpose of the Study:
- To explore the causal link between cancer cell molecular phenotype and cancer-associated thrombosis.
- To investigate how genetic and epigenetic factors in cancer influence the coagulome and prothrombotic mechanisms.
Main Methods:
- Review of emerging data on cancer cell genetics, epigenetics, and their interaction with the hemostatic system.
- Analysis of single-cell transcriptomic data from brain tumors to identify diverse coagulant mechanisms within cancer cell subpopulations.
Main Results:
- Cancer cell genetic and epigenetic drivers influence the 'coagulome,' affecting the hemostatic and inflammatory systems.
- Cancer cells release prothrombotic extracellular vesicles (EVs).
- Single-cell analysis reveals multiple, coexisting coagulant mechanisms within different cancer cell populations in brain tumors.
Conclusions:
- Cancer-associated thrombosis is biologically driven by cancer cell phenotype and genetic alterations.
- A multifaceted, biologically informed strategy is necessary for effective prediction and management of CAT.
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