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Related Concept Videos

Fatigue01:21

Fatigue

230
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
230
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

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Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
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Long-term Depression01:05

Long-term Depression

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Fatigue Strength of Concrete01:22

Fatigue Strength of Concrete

267
Fatigue, in the context of materials science and engineering, refers to the weakening or failure of a material caused by repeatedly applied loads, even if these loads are below the strength limit of the material. Fatigue strength in concrete is a critical property that influences its durability and longevity. Concrete can fail in two ways due to fatigue. Static fatigue or creep rupture occurs under a constant load or one that increases slowly. The other failure mode is due to cyclical or...
267
Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

96
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
96
Management of Insomnia01:19

Management of Insomnia

314
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
314

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Related Experiment Video

Updated: Aug 30, 2025

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model
05:38

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model

Published on: April 12, 2024

364

Post-COVID-19 fatigue: A systematic review.

Jian Joli1, Patrizia Buck1, Stephan Zipfel1

  • 1Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, Germany.

Frontiers in Psychiatry
|August 29, 2022
PubMed
Summary

Post-COVID-19 fatigue affects many adults, with risk factors including older age, female sex, and severe acute infection. Various treatments show promise, but more controlled studies are needed.

Keywords:
COVID-19brain fogetiologylong-COVIDpost-COVID fatiguepsychosomaticsymptomstherapy

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Last Updated: Aug 30, 2025

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The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
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Area of Science:

  • Medical Science
  • Public Health

Background:

  • Fatigue is a prevalent long-term symptom following SARS-CoV-2 infection.
  • Understanding its characteristics, causes, and effective treatments is crucial for patient recovery.

Approach:

  • Systematic review of 20 studies (5,629 participants) focusing on adult post-COVID-19 fatigue.
  • Analysis included demographics, clinical data, risk factors, and therapeutic interventions.
  • Excluded elderly patients and those with chronic fatigue-inducing conditions.

Key Points:

  • Risk factors identified: older age, female sex, severe acute COVID-19, comorbidities, and pre-existing depression/anxiety.
  • Potential autoimmune etiology is suggested.
  • Interventions like Chinese herbal medicine, molecular hydrogen, hyperbaric oxygen therapy, and physical therapy demonstrated some benefits.

Conclusions:

  • Post-COVID-19 fatigue is multifactorial, influenced by various risk factors.
  • Current therapeutic evidence is largely from small, uncontrolled trials.
  • Larger, controlled studies on physical and psychotherapy are urgently required to establish effective treatments.