Related Experiment Video
Updated: May 4, 2026
mirMachine: A One-Stop Shop for Plant miRNA Annotation
Published on: May 1, 2021
A review on the role of miRNA-324 in various diseases
Sepideh Kadkhoda1, Bashdar Mahmud Hussen2,3, Solat Eslami4,5
1Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Abstract:
Recent studies have revealed important functions of several microRNAs (miRNAs) in the pathogenesis of human diseases. miR-324 is an example of miRNAs with crucial impacts on the pathogenesis of a wide range of disorders. Gene ontology studies have indicated possible role of miR-324 in responses of cells to the leukemia inhibitory factor, long-term synaptic potentiation, positive regulation of cytokines production and sensory perception of sound. In human, miR-324 is encoded by MIR324 gene which resides on chromosome 17p13.1. In the current manuscript, we provide a concise review of the role of miR-324 in the pathogenesis of cancers as well as non-cancerous conditions such as aneurysmal subarachnoid hemorrhage, diabetic nephropathy, epilepsy, pulmonary/renal fibrosis, ischemic stroke and ischemia reperfusion injuries. Moreover, we summarize the role of this miRNA as a prognostic marker for malignant disorders.
Insights
MicroRNA-324 (miR-324) plays a significant role in various human diseases, including cancers and non-cancerous conditions. This review highlights its involvement in disease pathogenesis and its potential as a prognostic marker.
Area of Science:
- Molecular Biology
- Genetics
- Pathogenesis Research
Background:
- MicroRNAs (miRNAs) are critical regulators in human disease pathogenesis.
- miR-324, encoded by the MIR324 gene on chromosome 17p13.1, has emerged as a key miRNA with diverse biological functions.
- Gene ontology suggests miR-324 involvement in cellular responses, synaptic plasticity, cytokine production, and sensory perception.
Purpose of the Study:
- To provide a concise review of miR-324's role in the pathogenesis of various human diseases.
- To explore miR-324's involvement in both cancerous and non-cancerous conditions.
- To summarize the utility of miR-324 as a prognostic marker in malignant disorders.
Main Methods:
- Literature review of recent studies on microRNA functions.
- Analysis of gene ontology data related to miR-324.
- Synthesis of findings on miR-324's role in disease pathogenesis and prognosis.
Main Results:
- miR-324 is implicated in the pathogenesis of a wide range of disorders.
- Specific conditions reviewed include cancers, aneurysmal subarachnoid hemorrhage, diabetic nephropathy, epilepsy, fibrosis, and ischemic injuries.
- miR-324 demonstrates potential as a prognostic indicator for malignant diseases.
Conclusions:
- miR-324 is a significant miRNA involved in the pathogenesis of numerous human diseases.
- Its multifaceted roles extend to both oncological and non-oncological pathologies.
- miR-324 holds promise as a valuable prognostic biomarker in clinical settings.
More Related Videos
Related Concept Videos
01:29Penis
Anatomy of the Penis
The glans penis, or the head, is the terminal part of the penis and houses the external urethral orifice, the exit point for urine and semen. Covered by the prepuce, or foreskin, the glans is noted for its sensitivity and plays a key role in sexual pleasure. The body of the...
01:17Male Sexual Response: Erection & Ejaculation
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
01:20Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....