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Polymeric Microneedle Array Fabrication by Photolithography
Published on: November 17, 2015
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Microneedles for transdermal drug delivery using clay-based composites.
Farzaneh Sabbagh1, Beom Soo Kim1
1Department of Chemical Engineering, Chungbuk National University, Cheongju, Republic of Korea.
Expert Opinion on Drug Delivery
|August 29, 2022
Summary
Clay-based materials offer effective transdermal drug delivery by entrapping medications within their structure for controlled release. Modifying clay type and concentration allows for tunable drug release duration through the skin.
Area of Science:
- Materials Science
- Pharmaceutical Sciences
- Nanotechnology
Background:
- Clays possess unique structures enabling drug interaction and controlled release.
- Transdermal drug delivery bypasses hepatic metabolism by delivering drugs through the skin.
- Clay's ion-exchange capacity and layered structure facilitate high drug entrapment and release.
Purpose of the Study:
- To review clay-based polymer microneedles for drug delivery.
- To explore clay-drug interactions and antimicrobial properties.
- To compare key clay types (montmorillonite, halloysite, sepiolite) for transdermal applications.
Main Methods:
- Literature review of clay-based transdermal drug delivery systems.
- Analysis of clay-drug interaction mechanisms.
- Investigation of clay-drug composites for in vitro drug release studies.
Main Results:
- Clay-based systems demonstrate sustained drug release through the skin.
- Drug release duration can be modulated by altering polymer characteristics or clay type/concentration.
- 5 wt% clay concentration is identified as suitable for transdermal applications.
Conclusions:
- Clay materials are promising carriers for transdermal drug delivery.
- The tunable nature of clay-drug interactions allows for controlled release kinetics.
- Further research into specific clay types and formulations can optimize transdermal therapeutic systems.
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