High-intensity resistance training in people with multiple sclerosis experiencing fatigue: A randomised controlled...

Area of Science:

• Neurology
• Rehabilitation Medicine
• Exercise Science

Background:

• Fatigue is a primary concern for people with multiple sclerosis (PwMS).
• Limited research exists on exercise interventions specifically targeting fatigue in PwMS.

Purpose of the Study:

• To assess the impact of high-intensity resistance training (HIRT) on self-reported fatigue in fatigued PwMS.
• To compare the effectiveness of twice-weekly versus once-weekly HIRT sessions.

Main Methods:

• A randomized controlled trial involving 71 fatigued PwMS (Fatigue Scale for Motor and Cognitive Functions [FSMC] score ≥ 53).
• Participants were randomized to HIRT twice weekly (Group A) or once weekly (Group B) for 12 weeks.
• A non-randomized, matched control group (n=69) received no intervention.

Main Results:

• Both HIRT groups showed significant reductions in FSMC scores compared to the non-intervention control group (p<0.001).
• Group A (twice-weekly HIRT) demonstrated significant improvements in anxiety and psychological subscales of the Hospital Anxiety and Depression Scale and MS Impact Scale-29.
• Changes in plasma inflammatory markers were correlated with reduced fatigue scores.

Conclusions:

• High-intensity resistance training (HIRT) is effective in reducing self-reported fatigue in people with multiple sclerosis (PwMS).
• The observed reductions in fatigue are linked to changes in plasma inflammatory protein levels.
• HIRT is a recommended intervention for managing fatigue in PwMS.