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Updated: Aug 30, 2025
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Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria
Published on: October 4, 2024
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Six-Pointed Star Chiral Cobalt Superstructures with Strong Antibacterial Activity
Gaoyang Wang1, Changlong Hao1, Chen Chen1
1International Joint Research Laboratory for Biointerface and Biodetection, State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, P. R. China.
Small (Weinheim an Der Bergstrasse, Germany)
|August 29, 2022
Summary
Chiral cobalt superstructures show potent antibacterial activity against Staphylococcus aureus. D-enantiomers demonstrate enhanced efficacy due to increased reactive oxygen species generation, highlighting their potential in combating bacterial infections.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Chiral inorganic nanomaterials offer biocompatibility and optical properties for antibacterial applications.
- Developing novel chiral nanomaterials is crucial for advancing antimicrobial strategies.
Purpose of the Study:
- To synthesize and characterize diverse chiral cobalt superstructures (Co SS) using L/D-Tartaric acid ligands.
- To investigate the chiroptical, superparamagnetic, and antibacterial properties of the synthesized Co SS.
- To explore the mechanism behind the enhanced antibacterial activity of D-Co SS.
Main Methods:
- Synthesis of chiral Co SS with varying morphologies (nanoflowers, nanohanamaki, star, fan, fusiform) by adjusting L/D-Tartaric acid ratios.
- Characterization of chiroptical activity (300-1300 nm) and g-factor (0.033) of chiral six-pointed star structures.
- Evaluation of antibacterial efficacy against Staphylococcus aureus under electromagnetic fields.
- Quantification of reactive oxygen species (ROS) generation to elucidate antibacterial mechanisms.
Main Results:
- Diverse chiral Co SS morphologies were successfully synthesized.
- Chiral six-pointed star Co SS exhibited broad-spectrum chiroptical activity and superparamagnetism.
- Co SS demonstrated significant killing ability against Gram-positive Staphylococcus aureus.
- D-Co SS showed superior antibacterial activity compared to L-Co SS, attributed to 1.59-fold higher ROS generation.
Conclusions:
- Chiral cobalt superstructures, particularly the six-pointed star morphology, possess significant antibacterial potential.
- The enhanced antibacterial efficacy of D-Co SS is linked to chiral-induced spin selectivity effects and increased ROS production.
- These findings pave the way for developing advanced chiral materials for targeted antibacterial therapies.
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