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Extended Remdesivir Infusion for Persistent Coronavirus Disease 2019 Infection
Mario A Martinez1, Ting-Yi Chen2, Hosoon Choi3
1Division of Infectious Diseases, Baylor Scott and White Health, Temple, Texas, USA.
Open Forum Infectious Diseases
|August 30, 2022
Summary
Persistent infections with the virus causing COVID-19 (coronavirus disease 2019) are challenging. A 5-month persistent infection in an immunocompromised patient was successfully treated with 30 days of remdesivir.
Area of Science:
- Infectious Diseases
- Virology
- Immunocompromised Hosts
Background:
- Persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections pose significant treatment challenges.
- Immunocompromised individuals are at higher risk for prolonged viral infections.
Purpose of the Study:
- To report a case of prolonged coronavirus disease 2019 (COVID-19) in an immunocompromised patient.
- To evaluate the efficacy of extended remdesivir treatment for persistent SARS-CoV-2 infection.
Main Methods:
- A case study of a 5-month persistent COVID-19 infection.
- Treatment with 30 consecutive days of remdesivir infusion.
- Monitoring of viral load using cycle threshold (Ct) values.
Main Results:
- Successful treatment of a 5-month persistent SARS-CoV-2 infection.
- Resolution of infection following prolonged remdesivir administration.
- Correlation between Ct values and treatment response observed.
Conclusions:
- Prolonged remdesivir infusion may be a viable strategy for treating difficult-to-treat persistent SARS-CoV-2 infections.
- Concurrent cycle threshold monitoring can aid in managing these prolonged infections.
- This approach offers a potential solution for immunocompromised patients with persistent COVID-19.
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