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Potential Ophthalmological Side Effects Induced by Anti-Neoplastic Regimens for the Treatment of Genitourinary

Minas Sakellakis1, Nikolaos Spathas2, Konstantinos T Tsaousis3

  • 1Medical Oncology, Hellenic Genitourinary Cancer Group, Athens, GRC.

Cureus
|August 30, 2022
PubMed

Insights

Novel cancer therapies improve genitourinary (GU) cancer outcomes but can cause ocular side effects. This review details potential vision-threatening eye complications from GU cancer treatments.

Area of Science:

  • Ophthalmology
  • Oncology
  • Pharmacology

Background:

  • Genitourinary (GU) cancers have seen improved patient outcomes due to novel therapies.
  • New antineoplastic agents enhance survival and quality of life but increase side effect frequency.

Purpose of the Study:

  • To review potential ocular adverse reactions associated with genitourinary cancer treatments.
  • To highlight the spectrum of ocular toxicities from novel GU cancer therapies.

Main Methods:

  • Literature review of ocular toxicity associated with antineoplastic regimens for GU cancers.
  • Focus on treatments for prostate, bladder, renal cell, testicular, pheochromocytoma, adrenocortical, and penile cancers.

Main Results:

  • Ocular toxicity from GU cancer treatments presents a broad spectrum of manifestations.
  • While many side effects are mild and transient, some can be severe, disabling, or irreversible.
  • Clinicians must recognize vision-threatening complications impacting patient quality of life.

Conclusions:

  • Ocular adverse events are an important consideration in GU cancer treatment.
  • Awareness of potential eye complications is crucial for managing patients on novel antineoplastic therapies.
  • Early detection and management of ocular toxicity can preserve vision and quality of life.
Keywords:
adversecancerseffectsgenitourinaryophthalmologic

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