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Decrease in catalase activity of cultured cells by Mycoplasma gallisepticum infection.

T Nunoya, M Tajima, T Yagihashi

    Veterinary Microbiology
    |April 1, 1987
    PubMed
    Summary
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    Mycoplasma gallisepticum infection reduces host cell catalase activity in chicken cells. This decrease, linked to viable organism attachment, is crucial for developing cell damage.

    Area of Science:

    • * Veterinary Pathology
    • * Cell Biology
    • * Microbiology

    Background:

    • * Mycoplasma gallisepticum is a significant avian pathogen.
    • * Host cell catalase activity is vital for cellular defense.
    • * The interaction between M. gallisepticum and host cell enzymes is not fully understood.

    Purpose of the Study:

    • * To investigate the impact of Mycoplasma gallisepticum infection on host cell catalase activity.
    • * To determine the role of viable M. gallisepticum in altering catalase levels.
    • * To explore the relationship between catalase activity changes and cytopathic effects.

    Main Methods:

    • * Histochemical examination of catalase activity in cultured chicken embryo fibroblasts (CEF) and kidney cells.
    • * Infection of cell cultures with a CEF-passaged strain of M. gallisepticum and an original strain.

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  • * Comparison of catalase activity in cells infected with viable, UV-killed, and passage-adapted M. gallisepticum.

    • Main Results:

    • * Infection with a CEF-passaged M. gallisepticum strain significantly decreased catalase-positive granules in host cells.
    • * UV-killed M. gallisepticum and the original strain did not affect catalase levels.
    • * The CEF-passaged strain exhibited enhanced adherence and induced cytopathic effects.

    Conclusions:

    • * Viable M. gallisepticum attachment to host cells is essential for reducing catalase activity.
    • * Decreased catalase activity is a key factor in the development of M. gallisepticum-induced cytopathic effects.
    • * Understanding this mechanism can inform strategies for managing avian mycoplasmosis.