Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Macrophages de<i>liver</i> growth.

Science signaling·2025
Same author

Making sense of gastric cancer.

Science signaling·2025
Same author

Alarmin' lymphoid developments.

Science signaling·2025
Same author

In Science Journals.

Science (New York, N.Y.)·2025
Same author

Healing limited.

Science signaling·2024
Same author

Neurons go antiviral.

Science signaling·2024

Related Experiment Video

Updated: Aug 30, 2025

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells
07:22

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells

Published on: March 28, 2013

38.9K

Blocking beige fat biogenesis.

Amy E Baek1

  • 1Science Signaling, AAAS, Washington, DC 20005, USA.

Science Signaling
|August 30, 2022
PubMed
Summary

A newly identified ubiquitin E3 ligase complex restricts the creation of beige fat cells. This finding offers new insights into regulating energy expenditure and metabolic health.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Metabolic Research

Background:

  • Beige fat, a type of adipose tissue, plays a crucial role in thermogenesis and energy expenditure.
  • The regulation of beige fat biogenesis is complex and involves multiple molecular pathways.
  • Understanding the factors that control beige fat generation is essential for developing strategies against obesity and metabolic diseases.

Purpose of the Study:

  • To identify novel regulators of beige fat biogenesis.
  • To elucidate the molecular mechanisms by which these regulators control the generation of beige fat.
  • To investigate the therapeutic potential of targeting these regulators for metabolic disorders.

Main Methods:

  • Utilized CRISPR screening to identify genes involved in beige fat formation.

More Related Videos

Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging
08:31

Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging

Published on: July 1, 2021

3.2K
Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
06:08

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Published on: May 19, 2023

2.3K

Related Experiment Videos

Last Updated: Aug 30, 2025

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells
07:22

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells

Published on: March 28, 2013

38.9K
Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging
08:31

Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging

Published on: July 1, 2021

3.2K
Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
06:08

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Published on: May 19, 2023

2.3K
  • Performed biochemical assays to characterize the function of the identified ubiquitin E3 ligase complex.
  • Employed cell-based assays and animal models to validate the role of the complex in beige fat generation.

    • Main Results:

    • Identified a specific ubiquitin E3 ligase complex that negatively regulates beige fat biogenesis.
    • Demonstrated that this complex targets key transcription factors essential for beige adipogenesis.
    • Showcased that inhibiting the E3 ligase complex promotes beige fat formation and improves metabolic parameters in vivo.

    Conclusions:

    • A ubiquitin E3 ligase complex acts as a critical brake on beige fat generation.
    • Targeting this E3 ligase complex represents a potential therapeutic strategy for enhancing thermogenesis and combating metabolic dysfunction.
    • Further research into E3 ligase complexes could uncover new avenues for metabolic disease treatment.