[Characteristics of protein-DNA association in chromatin from epidermal cells in psoriasis]

Two forms of nucleoprotein complex alpha and beta were found in human keratinocytes by means of nucleoprotein celite chromatography. They were not observed any principal differences between distribution of chromatin various forms in impaired and normal skin of the patients with psoriasis as well as in skin of healthy persons. Only slight differences were detected in the ratio of radioactive DNA in alpha and beta forms of chromatin from impaired and normal keratinocytes, while tightly-bound DNA was increased in psoriasis. In psoriasis acceleration of keratinocyte cell cycle but not an increase in proliferating cells pool appear to occur.