The potential for treg-enhancing therapies in nervous system pathologies

Area of Science:

• Neuroimmunology
• Immunology
• Neurology

Background:

• Inflammation significantly contributes to the pathogenesis of numerous central and peripheral nervous system disorders.
• Chronic inflammation, driven by aberrant T-cell responses, leads to tissue damage and neuronal cell death.

Approach:

• This review examines the multifaceted roles of regulatory T cells (Tregs) in nervous system diseases.
• Focuses on the therapeutic potential of enhancing Treg function to counteract neuroinflammation.

Key Points:

• Regulatory T cells (Tregs) are essential for immune tolerance and homeostasis by suppressing immune responses.
• Tregs modulate T cell proliferation and pro-inflammatory cytokine production, thereby controlling autoimmunity.
• Evidence supports Treg involvement in the onset and progression of various neurological conditions.

Conclusions:

• Tregs play a critical role in managing neuroinflammatory responses and protecting against neuronal damage.
• Harnessing Treg-based therapies presents a viable strategy for treating a spectrum of neurological disorders, including neurodegenerative diseases and injuries.