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Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
Published on: January 20, 2023
Posttraumatic Headache
Morgan Heinzelmann1, Christine Woods2, Bert B Vargas3
1Department of Neurology, UT-Southwestern Medical Center, Dallas, Texas.
Posttraumatic headache (PTH) is a common secondary headache after concussion. Research is increasing, but its causes and treatments require further study.
Area of Science:
- Neurology
- Neuroscience
- Public Health
Background:
- Posttraumatic headache (PTH) is the most frequent secondary headache disorder.
- It is a common and potentially debilitating symptom following concussion (mild traumatic brain injury).
- Increased public awareness of traumatic brain injury has spurred more research into PTH.
Purpose of the Study:
- To review the current understanding of posttraumatic headache.
- To highlight the need for further research into its pathophysiology and treatment.
- To emphasize the diagnostic criteria and current treatment approaches for PTH.
Main Methods:
- Literature review of existing studies on posttraumatic headache.
- Analysis of diagnostic criteria and temporal relationship to head injury.
- Examination of current treatment strategies based on primary headache phenotypes.
Main Results:
- PTH is the most common secondary headache, affecting approximately 4% of headache disorder cases.
- Diagnosis relies on the temporal link to a head injury and often mimics primary headache types.
- No specific treatments are currently approved for PTH; existing therapies are repurposed.
Conclusions:
- The pathophysiology of PTH is not well understood and likely multifactorial.
- Further research is essential to refine PTH definition, elucidate mechanisms, and develop targeted treatments.
- Current management involves applying treatments used for other headache disorders.
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