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Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

104
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
104
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

42
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
42
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

66
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
66
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

74
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
74
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

73
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
73
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

65
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
65

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Related Experiment Video

Updated: Aug 30, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
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Prolonged Intermittent Kidney Replacement Therapy.

Zoey Levine1, Anitha Vijayan

  • 1Division of Nephrology, Washington University in St. Louis, St. Louis, Missouri.

Clinical Journal of the American Society of Nephrology : CJASN
|August 30, 2022
PubMed
Summary
This summary is machine-generated.

Prolonged intermittent kidney replacement therapy (KRT) offers hemodynamic stability and cost savings for critically ill patients with acute kidney injury (AKI). This adaptable KRT modality provides flexibility for patient mobilization and procedures, aiding recovery.

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Area of Science:

  • Nephrology
  • Critical Care Medicine
  • Renal Replacement Therapy

Background:

  • Kidney replacement therapy (KRT) is essential for severe acute kidney injury (AKI) in critical illness.
  • While continuous KRT and intermittent hemodialysis are standard, prolonged intermittent KRT is gaining traction globally.
  • Gaps persist in understanding optimal KRT timing, dose, and modality selection.

Purpose of the Study:

  • To review the growing prevalence and benefits of prolonged intermittent KRT.
  • To compare prolonged intermittent KRT with continuous KRT and intermittent hemodialysis.
  • To discuss challenges and recommendations for implementing prolonged intermittent KRT.

Main Methods:

  • Literature review and synthesis of existing studies on KRT modalities.
  • Comparative analysis of hemodynamic stability, cost-effectiveness, and patient management.
  • Discussion of prescription tailoring, dosing extrapolation, and practice variations.

Main Results:

  • Prolonged intermittent KRT provides comparable hemodynamic stability to continuous KRT with cost benefits.
  • It offers superior hemodynamic stability over intermittent hemodialysis, especially for hypotensive-vulnerable patients.
  • Treatment can be customized for patient recovery, with flexible frequency, flow rates, and duration.

Conclusions:

  • Prolonged intermittent KRT is a viable and adaptable KRT option, particularly in resource-limited settings.
  • Standardization of terminology, prescription, and dosing is crucial for effective implementation and drug management.
  • Collaborative planning among multidisciplinary teams is essential for successful institutional adoption.