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[Serum enzymes in hypothyroidism].

M Petkova, N Kolebinov, P Popivanov

    Vutreshni Bolesti
    |January 1, 1987
    PubMed
    Summary
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    Thyroid hormone levels impact key enzymes like creatine kinase (CK) and lactate dehydrogenase (LDH) in hypothyroidism. Monitoring these enzyme constellations aids in differentiating hypothyroidism from ischemic heart disease.

    Area of Science:

    • Biochemistry
    • Endocrinology
    • Clinical Diagnostics

    Background:

    • Primary hypothyroidism can affect various biochemical markers.
    • Elevated enzyme levels are often observed in untreated hypothyroidism.
    • Distinguishing cardiac enzyme changes in hypothyroidism from ischemic heart disease is clinically important.

    Purpose of the Study:

    • To investigate the enzyme profiles in newly diagnosed, untreated primary hypothyroidism patients.
    • To assess the changes in specific enzymes before and after thyroid hormone replacement therapy.
    • To evaluate the utility of enzyme constellation monitoring for differential diagnosis.

    Main Methods:

    • Studied 27 untreated primary hypothyroidism patients.
    • Measured TTH, CK (with MB isoenzyme), LDH (with LDH1 and LDH5), ASAT, and ALAT.

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  • Analyzed enzyme levels before and after 20-day substitutive therapy.

    • Main Results:

    • Approximately 60% of untreated patients showed elevated enzymes, with CK (MB), ASAT, and LDH1 being characteristic.
    • Myocardial isoenzymes normalized during substitutive therapy.
    • Elevated enzymes were primarily associated with increased CK levels.

    Conclusions:

    • The specific enzyme constellation in hypothyroidism aids in differential diagnosis with ischemic heart disease.
    • Creatine kinase (CK) determination can serve as a screening tool to guide further enzyme constellation studies.
    • Monitoring enzyme profiles during hypothyroidism treatment is valuable for clinical management.