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Updated: Aug 30, 2025

Multimodal 3D Printing of Phantoms to Simulate Biological Tissue

Multimodal 3D Printing of Phantoms to Simulate Biological Tissue

Published on: January 11, 2020

4D printing: a cutting-edge platform for biomedical applications.

Moqaddaseh Afzali Naniz¹, Mohsen Askari^2,3, Ali Zolfagharian⁴

¹Graduate School of Biomedical Engineering, University of New South Wales (UNSW), Sydney, NSW 2052, Australia.

Biomedical Materials (Bristol, England)

|August 31, 2022

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Four-dimensional (4D) printing uses smart materials to create dynamic, responsive structures. This advanced manufacturing technique overcomes the limitations of static 3D printing for biomedical applications.

Area of Science:

Biomedical Engineering
Materials Science
Additive Manufacturing

Background:

Natural materials exhibit dynamic responses to environmental stimuli.
Traditional 3D printing produces static objects, limiting functional adaptability.
Advancements in smart materials enable dynamic shape changes in response to stimuli.

Purpose of the Study:

To discuss the concept and advancements of four-dimensional (4D) bioprinting.
To explore the role of smart materials in creating responsive biomimetic structures.
To highlight the potential of 4D bioprinting in pharmaceutics and biomedical research.

Main Methods:

Review of recent developments in smart materials actuation.
Analysis of additive manufacturing techniques for 4D printing.

Keywords:

4D printing biomedical application drug delivery medical devices soft robotics tissue engineering

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Multimodal 3D Printing of Phantoms to Simulate Biological Tissue

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Published on: January 11, 2020

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Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

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Exploration of geometric design principles for dynamic morphing.

Main Results:

Smart materials can be actuated by various stimuli (e.g., temperature, light, pH).
4D printing enables the creation of complex, dynamic structures with tunable functions.
Biomimetic materials and structures with advanced properties are achievable.

Conclusions:

4D bioprinting integrates smart materials and additive manufacturing for dynamic biomedical applications.
This technology offers significant potential for developing innovative pharmaceutics and research tools.
Future prospects include enhanced biomimetic designs and expanded clinical applications.