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Splenium of the Corpus Callosum Infarct Associated With COVID-19: Case Report.

David A Karp¹, Gabriel Beaudoin^1,2, Robert A Egan^1,3,4

¹Alameda Highland Hospital, Department of Neurology, Oakland, CA.

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|August 31, 2022

Summary

This summary is machine-generated.

A young woman developed a central splenium lesion during acute COVID-19 infection. This case highlights the potential neurological complications of SARS-CoV-2, specifically affecting the corpus callosum.

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Area of Science:

Neurology
Infectious Diseases
Neuroimaging

Background:

Coronavirus disease 2019 (COVID-19) is increasingly linked to neurological complications.
Lesions in the central splenium of the corpus callosum have been observed in COVID-19 patients.
The predilection for this specific brain region in COVID-19 remains unclear.

Observation:

A 22-year-old female presented with altered mental status and tested positive for SARS-CoV-2.
Initial neurological assessment revealed somnolence and nonverbal status.
The patient's presentation suggested a significant neurological event potentially related to acute infection.

Findings:

The case presents a new instance of a central splenium lesion in a young adult with acute COVID-19.
This lesion is characterized as cytotoxic, with imaging typically showing minimal enhancement.
The findings support the association between COVID-19 and splenium lesions.

Implications:

This case contributes to understanding the spectrum of neurological manifestations of COVID-19.
Further research is needed to elucidate the mechanisms behind corpus callosum involvement in SARS-CoV-2 infection.
Identifying specific patterns of brain injury in COVID-19 is crucial for diagnosis and management.