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Updated: Aug 30, 2025

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
Published on: March 29, 2024
Long-term mortality in heart failure with mid-range ejection fraction: systematic review and meta-analysis
Deep Chandh Raja1,2,3,4, Indira Samarawickrema2,4, Souvik Das3,4
1Australian National University, Canberra, Australian Capital Territory, Australia.
Heart failure with mid-range ejection fraction (HFmrEF) shows a better prognosis than reduced ejection fraction (HFrEF) but a similar prognosis to preserved ejection fraction (HFpEF). Gender differences in studies may affect outcomes between HFmrEF and HFrEF.
Area of Science:
- Cardiology
- Heart Failure Research
- Clinical Outcomes
Background:
- Heart failure with mid-range ejection fraction (HFmrEF) presents clinical features overlapping with both reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF).
- Understanding the long-term prognosis of HFmrEF compared to other heart failure types is crucial for patient management.
Conclusions:
- HFmrEF is associated with a better prognosis than HFrEF but a comparable prognosis to HFpEF.
- Gender distribution within study populations may impact the comparative outcomes between HFmrEF and HFrEF.
- Further research is needed to explore the role of left ventricular ejection fraction (LVEF) transitions in determining heart failure outcomes.
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