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Neurobrucellosis presenting with the features of meningoencephalitis: A case report from Nepal

Aakash Acharya1, Anil Regmi2, Kabita Manandhar3

  • 1Department of Internal Medicine, Dr Iwamura Memorial Hospital, Sallaghari, Bhaktapur, Nepal.

Annals of Medicine and Surgery (2012)
|September 1, 2022
PubMed
Abstract

Insights

Neurobrucellosis, a serious complication of brucellosis, can mimic meningitis or encephalitis. Early diagnosis is crucial, especially in endemic areas, by considering Brucella infection when common causes are excluded.

Area of Science:

  • Infectious Diseases
  • Neurology
  • Zoonotic Diseases

Background:

  • Brucellosis is a zoonotic disease caused by Brucella species.
  • Neurobrucellosis is a rare but severe manifestation, often presenting with meningoencephalitis symptoms.

Observation:

  • A 13-year-old female with domestic animal exposure presented with meningoencephalitis features, including fever and seizures.
  • Clinical examination revealed lethargy, edema, and neck rigidity.

Findings:

  • Cerebral CT showed vasogenic edema.
  • Cerebrospinal fluid (CSF) analysis was unremarkable for common pathogens.
  • CSF ELISA confirmed the presence of Brucella antibodies, diagnosing neurobrucellosis.

Implications:

  • This case highlights the importance of considering neurobrucellosis in patients with meningoencephalitis symptoms, especially after ruling out other etiologies.
  • High index of suspicion and targeted serological testing (CSF ELISA) are vital for timely diagnosis in endemic regions.
Keywords:
BrucellaMeningoencephalitisNeurobrucellosis

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