Related Experiment Video
Updated: Aug 30, 2025
03:55
Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
599
Related factor analysis for predicting large-volume central cervical lymph node metastasis in papillary thyroid
Li Tan1, Jiaqi Ji1,2, Gaowa Sharen3
1Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Frontiers in Endocrinology
|September 1, 2022
Summary
Younger age, male gender, and specific ultrasound features are key risk factors for large-volume central cervical lymph node metastasis in papillary thyroid carcinoma. Chronic lymphocytic thyroiditis, however, shows a protective effect.
Area of Science:
- Oncology
- Endocrinology
- Radiology
Background:
- Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer.
- Central cervical lymph node metastasis (LNM) is a frequent occurrence in PTC.
- Identifying factors associated with large-volume LNM is crucial for treatment planning.
Purpose of the Study:
- To investigate the clinical and ultrasonographic factors associated with large-volume central cervical lymph node metastasis in papillary thyroid carcinoma.
- To identify independent risk factors and protective elements for extensive LNM in PTC.
Main Methods:
- Retrospective analysis of 340 patients with 642 PTC nodules treated between 2011 and 2015.
- Nodules were categorized into large-volume central cervical LNM (>5 metastatic nodes) and no LNM groups.
- Correlation analysis of patient demographics, chronic lymphocytic thyroiditis, and thyroid ultrasonographic features with LNM volume.
Main Results:
- Younger age (≤40 years), male gender, tumor macroaxis size, isthmus location, ill-defined margin, microcalcification, and abnormal cervical lymph nodes were identified as independent risk factors for large-volume LNM.
- Chronic lymphocytic thyroiditis was found to be a significant protective factor against large-volume LNM.
Conclusions:
- Factors such as younger age, male sex, and specific ultrasonographic findings predict a higher risk of large-volume central cervical LNM in PTC.
- Chronic lymphocytic thyroiditis may confer a protective effect, potentially influencing treatment strategies.
