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Near-Infrared Carbonized Polymer Dots for NIR-II Bioimaging
Tianyang Han1, Yajun Wang1,2, Shengjie Ma2,3
1State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, P. R. China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|September 1, 2022
Summary
Researchers developed near-infrared carbonized polymer dots (NIR-CPDs) for advanced bioimaging. These NIR-CPDs offer bright fluorescence in both NIR-I and NIR-II windows, enabling enhanced in vivo imaging applications.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Carbon dots (CDs) and carbonized polymer dots (CPDs) are promising optical materials with diverse applications.
- In vivo imaging necessitates CPDs emitting in the near-infrared-II (NIR-II) window (1000-1700 nm).
Purpose of the Study:
- To synthesize novel NIR-emissive CPDs (NIR-CPDs) for enhanced bioimaging.
- To enable high-performance in vivo imaging in both NIR-I and NIR-II transparent windows.
Main Methods:
- A two-step bottom-up synthesis strategy was employed.
- Hydrothermal reaction formed a carbon core with aldehyde groups.
- Knoevenagel reaction was used to attach molecular emission centers.
Main Results:
- The developed NIR-CPDs exhibit bright fluorescence in both NIR-I and NIR-II spectral regions.
- The synthesis is labor-saving, cost-efficient, and yields high quantities.
- NIR-CPDs demonstrated high-performance NIR-II angiography and real-time noninvasive imaging of colitis.
Conclusions:
- The novel NIR-CPDs are suitable for advanced in vivo imaging applications.
- This synthesis strategy offers a pathway for rational molecular engineering of NIR-emissive CPDs.
- The technology holds potential for next-generation CPD development with tunable optical properties.
